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Sevelamer HCl
CAS No. 152751-57-0
Sevelamer HCl( —— )
Catalog No. M12141 CAS No. 152751-57-0
Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 45 | In Stock |
|
| 100MG | 61 | In Stock |
|
| 200MG | 112 | In Stock |
|
| 500MG | 216 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSevelamer HCl
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NoteResearch use only, not for human use.
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Brief DescriptionSevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
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DescriptionSevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
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In VitroSevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL).
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In VivoSevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice.Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice.Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number152751-57-0
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Formula Weight186.08
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Molecular Formula(C?H?N . C?H?ClO)x . x HCl
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Purity>98% (HPLC)
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SolubilityDMSO:<1 mg/mL; Ethanol:<1 mg/mL; Water:<1 mg/mL
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SMILESC=CCN.C1C(O1)CCl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Katsumata K, et al. Kidney Int, 2003, 64(2), 441-450.
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