Sevelamer HCl( —— )

Catalog No. M12141 CAS No. 152751-57-0

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Product Name

Sevelamer HCl
Note

Research use only, not for human use.
Brief Description

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
Description

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.
In Vitro

Sevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL).
In Vivo

Sevelamer hydrochloride (1% mixed in diet; p.o.; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice.Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/- mice.Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression.
Synonyms

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Pathway

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Target

Other Targets
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Research Area

Other Indications
Indication

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1.Katsumata K, et al. Kidney Int, 2003, 64(2), 441-450.

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